DNP due to hamstring injury
Kirk was held out of practice Wednesday due to a hamstring injury.
Houston acquired Kirk from the Jaguars in early March for a 2026 seventh-round pick, after which he and the Texans reworked his contract by the end of that month. He seemingly locked up the No. 2 WR role behind Nico Collins by mid-August, but a new health concern now may threaten his availability for Week 1 and beyond. Getting back on the practice field Thursday and/or Friday will be key for Kirk's potential to play Sunday at the Rams, but if he's limited or out this weekend, rookies Jayden Higgins and Jaylin Noel would be in line for more targets from QB C.J. Stroud.
More San Francisco 49ers Fantasy Football News
Jake Tonges
Injury believed to be serious
Coach Kyle Shanahan said after Thursday night's win over the Rams that Tonges' knee injury "does not look good," Vic Tafur of The Athletic reports.
De'Zhaun Stribling
Avoids Achilles injury
Stribling (ankle) avoided an Achilles injury Thursday against the Rams after initial tests revealed his Achilles is intact, James Palmer of The Athletic reports.
Christian McCaffrey
Efficient with modest workload
McCaffrey rushed 10 times for 68 yards and brought in five of eight targets for 20 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.
Jake Tonges
Will not return Thursday
Tonges (knee) will not return to Thursday's game against the Rams, Brooke Evans of the 49ers' official website reports.
Jake Tonges
Questionable to return Thursday
Tonges (knee) is questionable to return to Thursday's game against the Rams, Nick Wagoner of ESPN.com reports.
De'Zhaun Stribling
Ruled out for remainder of Thursday's game
Stribling (ankle) has been ruled out for the remainder of Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
De'Zhaun Stribling
Leaves game again Thursday
Stribling had to be helped off the field and headed back to the blue medical tent during Thursday's game against the Rams after appearing to re-injure his left ankle, Matt Barrows of The Athletic reports.
De'Zhaun Stribling
Returns to Thursday's game
Stribling (ankle) returned to Thursday's game against the Rams, Jennifer Lee Chan of NBC Sports Bay Area reports.
De'Zhaun Stribling
Questionable to return Thursday
Stribling (ankle) is questionable to return to Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
Jordan James
Inactive Thursday
James (coach's decision) is officially inactive for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.