Efficient with modest workload

McCaffrey rushed 10 times for 68 yards and brought in five of eight targets for 20 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.

Coming off a 2025 regular season where he was able to suit up for all 17 games while handling 413 total touches, McCaffrey saw a notable workload reduction to open the new campaign. Rookie third-round pick Kaelon Black actually outpaced McCaffrey by four carries, but it was the latter who edged out his new backfield mate for the team lead in rushing yards. McCaffrey flashed his trademark explosiveness when carrying the ball and should still helm the ground attack on the majority of weeks, although lopsided game scripts in either direction could lead to head coach Kyle Shanahan taking the opportunity to curtail his star running back's volume. McCaffrey will next take aim at what is expected to be a vulnerable Dolphins defense in a Week 2 matchup on Sunday, Sept. 20.

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More San Francisco 49ers Fantasy Football News

Mike Evans

Mike Evans

WR SF

Clicks quickly with Purdy

Evans secured six of seven targets for 49 yards and a touchdown during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.

Brock Purdy

Brock Purdy

QB SF

Three-TD effort to open season

Purdy completed 25 of 34 passes for 205 yards with three touchdowns and one interception while adding five rushes for 29 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.

Jake Tonges

Jake Tonges

TE SF

Injury believed to be serious

Coach Kyle Shanahan said after Thursday night's win over the Rams that Tonges' knee injury "does not look good," Vic Tafur of The Athletic reports.

Avoids Achilles injury

Stribling (ankle) avoided an Achilles injury Thursday against the Rams after initial tests revealed his Achilles is intact, James Palmer of The Athletic reports.

Jake Tonges

Jake Tonges

TE SF

Will not return Thursday

Tonges (knee) will not return to Thursday's game against the Rams, Brooke Evans of the 49ers' official website reports.

Leaves game again Thursday

Stribling had to be helped off the field and headed back to the blue medical tent during Thursday's game against the Rams after appearing to re-injure his left ankle, Matt Barrows of The Athletic reports.