Inactive Thursday
James (coach's decision) is officially inactive for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
The 2025 fifth-rounder will not suit up in Week 1, leaving Christian McCaffrey and rookie third-rounder Kaelon Black as the only healthy running backs active for the 49ers on Thursday. James' role moving forward may depend on how effective Black is to start the season.
More San Francisco 49ers Fantasy Football News
Jake Tonges
Will not return Thursday
Tonges (knee) will not return to Thursday's game against the Rams, Brooke Evans of the 49ers' official website reports.
Jake Tonges
Questionable to return Thursday
Tonges (knee) is questionable to return to Thursday's game against the Rams, Nick Wagoner of ESPN.com reports.
De'Zhaun Stribling
Ruled out for remainder of Thursday's game
Stribling (ankle) has been ruled out for the remainder of Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
De'Zhaun Stribling
Leaves game again Thursday
Stribling had to be helped off the field and headed back to the blue medical tent during Thursday's game against the Rams after appearing to re-injure his left ankle, Matt Barrows of The Athletic reports.
De'Zhaun Stribling
Returns to Thursday's game
Stribling (ankle) returned to Thursday's game against the Rams, Jennifer Lee Chan of NBC Sports Bay Area reports.
De'Zhaun Stribling
Questionable to return Thursday
Stribling (ankle) is questionable to return to Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
George Kittle
In clear to play Week 1
Kittle (Achilles) isn't listed on the 49ers' injury report ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
George Kittle
Remains limited Wednesday
Kittle (Achilles) remained limited in Wednesday's practice, Nick Wagoner of ESPN.com reports.
George Kittle
Could see limited Week 1 role
Coach Kyle Shanahan said Tuesday that Kittle (Achilles) could have his workload monitored against the Rams on Thursday, Matt Maiocco of NBC Sports Bay Area reports.
Nick Bosa
Limited in practice Tuesday
Bosa (knee) was limited in Tuesday's practice, Matt Maiocco of NBC Sports Bay Area reports.