Saquon Barkley, RB (PHI)

Not practicing to begin week

Giants head coach Joe Judge said Barkley (ankle) won't participate in Wednesday's practice, Zack Rosenblatt of The Newark Star-Ledger reports.

Judge has thus far been reluctant to definitively rule Barkley out for Sunday's game against the Rams, but that appears to be a foregone conclusion after the running back suffered a left low-ankle sprain in the Giants' Week 5 loss to the Cowboys. Sources familiar with Barkley's injury expect him to miss 2-to-3 weeks, so barring a miraculous recovery over the next two days, he'll likely be ruled out for the matchup with the Rams by the end of the week. Devontae Booker stepped in as the Giants' clear lead back when Barkley exited in the loss to the Cowboys, carrying 16 times for 42 yards and a touchdown while hauling in three of four targets for 16 yards and another score.

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Jalen Hurts

Jalen Hurts

QB PHI

Likely to miss rest of season

Hurts (calf) is expected to be held out of football activities for multiple months and miss the rest of the season after new imaging over the weekend revealed several blood clots in his lungs, Tom Pelissero of Netflix reports.

Tanner McKee

Tanner McKee

QB PHI

Unremarkable in Week 6 start

McKee completed 26 of 45 passes for 215 yards with a touchdown and no interceptions while adding one carry for no gain in the Eagles' 25-14 loss to the Panthers on Sunday. He also recovered a fumble.

Dameon Pierce

Dameon Pierce

RB PHI

Logs 16 touches in lead role

Pierce rushed 12 times for 35 yards and a touchdown and brought in four of five targets for 15 yards in the Eagles' 25-14 loss to the Panthers on Sunday.

DeVonta Smith

DeVonta Smith

WR PHI

Looks good in return

Smith brought in seven of 14 targets for 75 yards and a touchdown in the Eagles' 25-14 loss to the Panthers on Sunday.

Returns Sunday

Wicks (undisclosed) returned to Sunday's contest versus the Panthers, Brooks Kubena of The Athletic reports.