Ruled out for Sunday
Samuel (hamstring) has been ruled out for Sunday's game against the Raiders, Nick Wagoner of ESPN.com reports.
Neither Samuel nor Mike Evans (Achilles) made a serious bid to play in San Francisco's first game after a Week 8 bye. Jordan Watkins, Brandin Cooks and Jacob Cowing are the healthy WRs on the active roster, with Demarcus Robinson (ankle) a candidate to come off injured reserve this week or next.
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Christian McCaffrey
Set to play Sunday
McCaffrey (hamstring) doesn't have a designation for Sunday's game versus the Raiders, Nick Wagoner of ESPN.com reports.
Mike Evans
Won't play Sunday
Evans (Achilles) has been ruled out for Sunday's game against the Raiders, Nick Wagoner of ESPN reports.
Christian Kirk
May need meniscus surgery
Kirk (knee) will miss Sunday's game against Las Vegas and may need surgery for a meniscus injury, David Lombardi of SFStandard.com reports.
Deebo Samuel Sr.
Misses open portion of practice
Samuel (hamstring) didn't participate in the early portion of Friday's practice, Nick Wagoner of ESPN.com reports.
Christian McCaffrey
Practicing Friday
McCaffrey (hamstring) took part in the open portion of Friday's practice, Nick Wagoner of ESPN reports.
Mike Evans
Not seen at Friday's practice
Evans (Achilles) didn't participate in the portion of Friday's practice open to the media, Nick Wagoner of ESPN.com reports.
Brandon Aiyuk
Money owed may be hurdle in securing release
Aiyuk's effort to secure his release by reporting to the 49ers' facility Friday could be complicated by roughly $13 million in bonus forfeiture he owes the team, Tom Pelissero of NFL Network reports.
Demarcus Robinson
Remains limited Thursday
Robinson (ankle) practiced on a limited basis Thursday.
Christian Kirk
Doesn't practice Thursday
Kirk (knee) didn't practice Thursday, Sam Warren of The Athletic reports.
Deebo Samuel Sr.
DNP on Thursday
Samuel (hamstring) was a non-participant at Thursday's practice, Sam Warren of The Athletic reports.