May practice, play this week
McCaffrey (hamstring) said Wednesday that he has a chance to practice this week and play Sunday against the Raiders, Nick Wagoner of ESPN.com reports.
McCaffrey toughed out what eventually was revealed to be a mild left hamstring strain during a Week 7 loss in Atlanta, when he finished with 13 touches for 100 yards from scrimmage and one rushing TD. With the benefit of a Week 8 bye, he said Wednesday that he feels "great," but chances for on-field work await for him Thursday and Friday.
More San Francisco 49ers Fantasy Football News
Deebo Samuel Sr.
No practice Wednesday
Samuel (hamstring) won't take part in practice Wednesday, Cam Inman of The San Jose Mercury News reports.
Mike Evans
Won't practice Wednesday
Head coach Kyle Shanahan said Evans (Achilles/ribs) won't practice Wednesday, NFL reporter Andrew Siciliano reports.
Christian McCaffrey
Will not practice Wednesday
McCaffrey (hamstring) will not participate in Wednesday's practice, Cam Inman of Bay Area News Group reports.
Brandon Aiyuk
Turns in reinstatement paperwork
Aiyuk, who who is currently is on the 49ers' Reserve/Left Squad list, has turned in paperwork to be reinstated, Adam Schefter of ESPN reports.
De'Zhaun Stribling
Progressing in recovery
Stribling (ankle) was spotted Monday walking without crutches or a brace on his lower leg, Matt Barrows of The Athletic reports.
Brandon Aiyuk
Pursuing return to NFL
Aiyuk is close to hiring new representation and is expected to file for reinstatement to the NFL in the near future, according to NFL reporter Jordan Schultz.
DeForest Buckner
Headed back to San Francisco
The 49ers acquired Buckner from the Colts on Tuesday in exchange for a 2027 fourth-round draft pick, Tom Pelissero of Netflix reports.
Christian Kirk
Blanked in 2026 debut
Kirk played 20 snaps on offense but didn't show up on the box score otherwise during Sunday's 29-20 loss to Atlanta.
Brandin Cooks
Only one catch vs. Atlanta
Cooks caught one of three targets for 13 yards during Sunday's 29-20 loss to Atlanta.
Jacob Cowing
Season-high output sans Evans and Samuel
Cowing caught three of five passes for 38 yards, added a 10-yard carry and returned one kickoff for 28 yards during Sunday's 29-20 loss to the Falcons.