Won't return Sunday
Barkley (hamstring) has been ruled out for the rest of Sunday's game against the Rams, Zach Berman of The Athletic reports.
Barkley tweaked his hamstring on a six-yard run in the first quarter, and the injury is severe enough for the star running back to be sidelined for the rest of Sunday's game. Tank Bigsby and Will Shipley will handle backfield duties the rest of the way in Barkley's absence.
More Philadelphia Eagles Fantasy Football News
Saquon Barkley
Injures hamstring in Week 4
Barkley suffered a hamstring injury during Sunday's game against the Rams, Olivia Reiner of the Philadelphia Inquirer reports.
Saquon Barkley
Enters medical tent in first quarter
Barkley (lower body) made his way to the sideline slowly and then entered the medical tent during the first quarter of Sunday's game against the Rams, Olivia Reiner of the Philadelphia Inquirer reports.
DeVonta Smith
Could miss multiple games
Smith (hamstring), who has been ruled out for Sunday's game against the Rams, is viewed "at very best, questionable" for the Eagles' Week 5 game versus the Jaguars in London, Mike Garafolo of NFL Network reports.
Andy Dalton
Slides to third on depth chart
Dalton is expected to serve as the Eagles' No. 3 quarterback for Sunday's game against the Rams, while Tanner McKee moves up to second on the depth chart as the top backup to Jalen Hurts, Mike Garafolo of NFL Network reports.
Tanner McKee
Replacing Dalton as No. 2 quarterback
McKee is expected to be active for Sunday's game against the Rams as the top backup to starter Jalen Hurts, while Andy Dalton serves as the Eagles' No. 3 quarterback, Mike Garafolo of NFL Network reports.
Zach Ertz
Back up on active roster
The Eagles elevated Ertz from the practice squad to the active roster Saturday ahead of Sunday's game against the Rams.
Makai Lemon
Larger role sans Smith
Lemon and Dontayvion Wicks will both operate in larger roles against the Rams on Sunday due to the absence of DeVonta Smith (hamstring), Chris McPherson of the Eagles' official site reports.
Dontayvion Wicks
Philly's WR1 for Week 4
Wicks will operate as the top wide receiver against the Rams on Sunday due to the absence of DeVonta Smith (hamstring), Chris McPherson of the Eagles' official site reports.
DeVonta Smith
Ruled out for Week 4
Smith (hamstring) has been ruled out for Sunday's contest against the Rams.
Dallas Goedert
Ruled out for Week 4
Goedert (knee) has been ruled out for Sunday's game against the Rams.