Indianapolis Colts @ Houston Texans – 1 (48)
This total opened up at 47 and has since climbed to 48. Each team has the same implied team total of 23.5, which is tops in the NFL this weekend. Andrew Luck and Deshaun Watson are the top two fantasy options at the quarterback position this weekend. Luck finished as QB4 while Watson finished as QB5. These two teams combined for 116 points in their two games this season and this is by far the friendliest fantasy environment on the slate. T.Y. Hilton and DeAndre Hopkins are the top two options at the wideout position. Lamar Miller and Marlon Mack will be very touchdown dependent this week, and make for contrarian plays only if you decide to fade either QB. Both teams have strong run defenses.