No practice Wednesday
Coach Kyle Shanahan said Kittle (ankle) won't practice Wednesday but "has a chance" to play Sunday against the Bears, Nick Wagoner of ESPN.com reports.
Kittle was tackled awkwardly on his seventh and final catch in the middle of the third quarter of Monday's win at Indianapolis and wasn't able to return. Shanahan told Wagoner afterward that it was too early to touch on the severity of Kittle's ankle injury before Jeremy Fowler of ESPN.com reported Tuesday that Kittle was tending to a mid-to-low ankle sprain. Kittle doesn't necessarily need to practice in order to be active Sunday against the Bears, but his chances to play Week 17 would increase if he's able to mix into drills at some point Thursday or Friday. Jake Tonges likely would step into the pass-catching role in the 49ers offense if Kittle isn't able to suit up this weekend.
More San Francisco 49ers Fantasy Football News
Brandon Aiyuk
Remains on left squad list
San Francisco general manager John Lynch told reporters Saturday that Aiyuk (knee) will remain on the 49ers' reserve/left squad list, Adam Schefter of ESPN reports.
George Kittle
Starting training camp on PUP
The 49ers placed Kittle (Achilles) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports.
Christian McCaffrey
Wins Best Comeback Athlete
McCaffrey was named the Best Comeback Athlete at the 2026 ESPYS, Briana Jeannel of the 49ers' official site reports.
Ricky Pearsall
Poised to start opposite Evans
Pearsall is expected to enter training camp as San Francisco's starting wide receiver opposite Mike Evans, Kyle Madson of USA Today reports.
Brock Purdy
Plans throwing sessions before camp
Purdy, who has been participating in this week's Tight End University, an event hosted by teammate George Kittle (Achilles), said that he plans to gather with other 49ers for throwing sessions over the next month prior to training camp, David Lombardi of the San Francisco Standard reports.
Brandon Aiyuk
Interested in joining Commanders
In a video posted to Instagram Wednesday, Aiyuk (knee) said that if the 49ers released him, he'd sign with the Commanders "tomorrow," ESPN.com reports.
George Kittle
Feels on track for Week 1
Kittle (Achilles) said Tuesday that he feels "definitely on track" for Week 1 though "nothing is 100 percent certain," David Lombardi of SFStandard.com reports.
George Kittle
Says he's ahead of schedule
Kittle (Achilles) said Wednesday that he's "doing great" and is "ahead of schedule" in his rehab, ESPN.com's Nick Wagoner reports.
Mike Evans
Winning over teammates and coaches
Evans is making a strong impression at voluntary OTAs and feels rejuvenated after an injury-plagued 2025, Matt Barrows of The Athletic reports.
Brandon Aiyuk
Issued arrest warrant for speeding
Aiyuk (knee) has been issued an arrest warrant on a misdemeanor charge of exhibition of speed by the Santa Clara County District Attorney's Office, David Lombardi of SFStandard.com reports.