Outplays Jonathan Taylor on MNF
McCaffrey handled 21 carries for 117 yards and caught six of eight targets for 29 yards and a pair of touchdowns in Monday's 48-27 win over Indianapolis.
McCaffrey and the Colts' Jonathan Taylor headlined a matchup featuring two of the league's top running backs on Monday Night Football. CMC got the better of Taylor (16-46-1) despite facing the stiffer of the two defenses, doubling the latter's yards from scrimmage and scoring output in a winning effort. McCaffrey pushed his rushing total over the 1,000-yard mark for the season while sitting 151 yards shy of doing the same as a receiver with two games left in the regular season. With the 49ers having a potential path to the No. 1 seed in the NFC, fantasy managers can expect the team to lean heavily on McCaffrey against the Bears in Week 17, especially if star TE George Kittle (ankle) is unable to suit up.
More San Francisco 49ers Fantasy Football News
George Kittle
Says he's ahead of schedule
Kittle (Achilles) said Wednesday that he's "doing great" and is "ahead of schedule" in his rehab, ESPN.com's Nick Wagoner reports.
Mike Evans
Winning over teammates and coaches
Evans is making a strong impression at voluntary OTAs and feels rejuvenated after an injury-plagued 2025, Matt Barrows of The Athletic reports.
Brandon Aiyuk
Issued arrest warrant for speeding
Aiyuk (knee) has been issued an arrest warrant on a misdemeanor charge of exhibition of speed by the Santa Clara County District Attorney's Office, David Lombardi of SFStandard.com reports.
Christian McCaffrey
Downplays workload concerns
McCaffrey said after Thursday's OTAs that he's looking forward to sustaining another heavy workload in 2026, and that any reductions in touches should come in practice rather than games, Nick Wagoner of ESPN.com reports.
George Kittle
Still targeting Week 1
Kittle (Achilles) said Wednesday that he is still targeting the 49ers' regular-season opener against the Rams in Week 1 as his return date, Cameron DaSilva of USA Today reports.
Mac Jones
Gets raise for 2026
Jones agreed to terms Wednesday on a contract restructure with the 49ers that adds a $300,000 roster bonus for 2026, Tom Pelissero of NFL Network reports.
Jordan James
Could be headed for No. 2 RB role
James "seems the most likely" of San Francisco's running backs behind Christian McCaffrey to earn the No. 2 role for the upcoming campaign, Nick Wagoner of ESPN.com reports.
De'Zhaun Stribling
Pick motivated by intangibles?
The 49ers' selection of Stribling at No. 33 overall in the 2026 NFL Draft was partially motivated by the organization's strong belief in his personality, leadership and work ethic, according to Matt Barrow of The Athletic.
Kaelon Black
In RB2 mix behind CMC
Black is set to compete with recent draft picks Jordan James and Isaac Guerendo for backup touches behind Christian McCaffrey, Grant Gordon of NFL.com reports.
George Kittle
Aiming to play Week 1
Coach Kyle Shanahan said Thursday that Kittle (Achilles) is aiming to be ready for the 49ers' Week 1 game against the Rams, David Lombardi of SFStandard.com reports.