Outplays Jonathan Taylor on MNF
McCaffrey handled 21 carries for 117 yards and caught six of eight targets for 29 yards and a pair of touchdowns in Monday's 48-27 win over Indianapolis.
McCaffrey and the Colts' Jonathan Taylor headlined a matchup featuring two of the league's top running backs on Monday Night Football. CMC got the better of Taylor (16-46-1) despite facing the stiffer of the two defenses, doubling the latter's yards from scrimmage and scoring output in a winning effort. McCaffrey pushed his rushing total over the 1,000-yard mark for the season while sitting 151 yards shy of doing the same as a receiver with two games left in the regular season. With the 49ers having a potential path to the No. 1 seed in the NFC, fantasy managers can expect the team to lean heavily on McCaffrey against the Bears in Week 17, especially if star TE George Kittle (ankle) is unable to suit up.
More San Francisco 49ers Fantasy Football News
Brandon Aiyuk
Remains on left squad list
San Francisco general manager John Lynch told reporters Saturday that Aiyuk (knee) will remain on the 49ers' reserve/left squad list, Adam Schefter of ESPN reports.
George Kittle
Starting training camp on PUP
The 49ers placed Kittle (Achilles) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports.
Christian McCaffrey
Wins Best Comeback Athlete
McCaffrey was named the Best Comeback Athlete at the 2026 ESPYS, Briana Jeannel of the 49ers' official site reports.
Ricky Pearsall
Poised to start opposite Evans
Pearsall is expected to enter training camp as San Francisco's starting wide receiver opposite Mike Evans, Kyle Madson of USA Today reports.
Brock Purdy
Plans throwing sessions before camp
Purdy, who has been participating in this week's Tight End University, an event hosted by teammate George Kittle (Achilles), said that he plans to gather with other 49ers for throwing sessions over the next month prior to training camp, David Lombardi of the San Francisco Standard reports.
Brandon Aiyuk
Interested in joining Commanders
In a video posted to Instagram Wednesday, Aiyuk (knee) said that if the 49ers released him, he'd sign with the Commanders "tomorrow," ESPN.com reports.
George Kittle
Feels on track for Week 1
Kittle (Achilles) said Tuesday that he feels "definitely on track" for Week 1 though "nothing is 100 percent certain," David Lombardi of SFStandard.com reports.
George Kittle
Says he's ahead of schedule
Kittle (Achilles) said Wednesday that he's "doing great" and is "ahead of schedule" in his rehab, ESPN.com's Nick Wagoner reports.
Mike Evans
Winning over teammates and coaches
Evans is making a strong impression at voluntary OTAs and feels rejuvenated after an injury-plagued 2025, Matt Barrows of The Athletic reports.
Brandon Aiyuk
Issued arrest warrant for speeding
Aiyuk (knee) has been issued an arrest warrant on a misdemeanor charge of exhibition of speed by the Santa Clara County District Attorney's Office, David Lombardi of SFStandard.com reports.