Career night on MNF
Purdy completed 25 of 34 pass attempts for 295 yards, five touchdowns and one interception while taking two carries for 11 yards in Monday's 48-27 rout of the Colts.
Purdy took his game to new heights by throwing five touchdown passes in a game for the first time in his career. The 25-year-old attacked Indianapolis' reeling secondary from the onset, firing three scores to three different receivers on San Francisco's first three possessions Monday. Purdy has been on an absolute heater coming out of the 49ers' bye week, amassing 590 passing yards and eight touchdowns without ever being forced to punt in both starts. The Iowa State Cyclone did lose star TE George Kittle (7-115-1) to an ankle injury in the second half, so Purdy could be missing one of his top weapons against the Bears in Week 17.
More San Francisco 49ers Fantasy Football News
Brandon Aiyuk
Remains on left squad list
San Francisco general manager John Lynch told reporters Saturday that Aiyuk (knee) will remain on the 49ers' reserve/left squad list, Adam Schefter of ESPN reports.
George Kittle
Starting training camp on PUP
The 49ers placed Kittle (Achilles) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports.
Christian McCaffrey
Wins Best Comeback Athlete
McCaffrey was named the Best Comeback Athlete at the 2026 ESPYS, Briana Jeannel of the 49ers' official site reports.
Ricky Pearsall
Poised to start opposite Evans
Pearsall is expected to enter training camp as San Francisco's starting wide receiver opposite Mike Evans, Kyle Madson of USA Today reports.
Brock Purdy
Plans throwing sessions before camp
Purdy, who has been participating in this week's Tight End University, an event hosted by teammate George Kittle (Achilles), said that he plans to gather with other 49ers for throwing sessions over the next month prior to training camp, David Lombardi of the San Francisco Standard reports.
Brandon Aiyuk
Interested in joining Commanders
In a video posted to Instagram Wednesday, Aiyuk (knee) said that if the 49ers released him, he'd sign with the Commanders "tomorrow," ESPN.com reports.
George Kittle
Feels on track for Week 1
Kittle (Achilles) said Tuesday that he feels "definitely on track" for Week 1 though "nothing is 100 percent certain," David Lombardi of SFStandard.com reports.
George Kittle
Says he's ahead of schedule
Kittle (Achilles) said Wednesday that he's "doing great" and is "ahead of schedule" in his rehab, ESPN.com's Nick Wagoner reports.
Mike Evans
Winning over teammates and coaches
Evans is making a strong impression at voluntary OTAs and feels rejuvenated after an injury-plagued 2025, Matt Barrows of The Athletic reports.
Brandon Aiyuk
Issued arrest warrant for speeding
Aiyuk (knee) has been issued an arrest warrant on a misdemeanor charge of exhibition of speed by the Santa Clara County District Attorney's Office, David Lombardi of SFStandard.com reports.