Won't play Week 16
Pearsall (knee/ankle) has been ruled out for Monday's game against the Colts, Matt Maiocco of NBC Sports Bay Area reports.
Pearsall was unable to participate in practice during Week 16 prep due to knee and ankle injuries that he sustained during the 49ers' Week 15 victory over the Titans. With Pearsall sidelined for Monday's road contest, Kendrick Bourne and Demarcus Robinson will step into larger roles on offense. Pearsall will work on progressing enough in his recovery to be available for the 49ers' Week 17 home tilt against the Bears on Sunday, Dec. 28.
More San Francisco 49ers Fantasy Football News
George Kittle
Says he's ahead of schedule
Kittle (Achilles) said Wednesday that he's "doing great" and is "ahead of schedule" in his rehab, ESPN.com's Nick Wagoner reports.
Mike Evans
Winning over teammates and coaches
Evans is making a strong impression at voluntary OTAs and feels rejuvenated after an injury-plagued 2025, Matt Barrows of The Athletic reports.
Brandon Aiyuk
Issued arrest warrant for speeding
Aiyuk (knee) has been issued an arrest warrant on a misdemeanor charge of exhibition of speed by the Santa Clara County District Attorney's Office, David Lombardi of SFStandard.com reports.
Christian McCaffrey
Downplays workload concerns
McCaffrey said after Thursday's OTAs that he's looking forward to sustaining another heavy workload in 2026, and that any reductions in touches should come in practice rather than games, Nick Wagoner of ESPN.com reports.
George Kittle
Still targeting Week 1
Kittle (Achilles) said Wednesday that he is still targeting the 49ers' regular-season opener against the Rams in Week 1 as his return date, Cameron DaSilva of USA Today reports.
Mac Jones
Gets raise for 2026
Jones agreed to terms Wednesday on a contract restructure with the 49ers that adds a $300,000 roster bonus for 2026, Tom Pelissero of NFL Network reports.
Jordan James
Could be headed for No. 2 RB role
James "seems the most likely" of San Francisco's running backs behind Christian McCaffrey to earn the No. 2 role for the upcoming campaign, Nick Wagoner of ESPN.com reports.
De'Zhaun Stribling
Pick motivated by intangibles?
The 49ers' selection of Stribling at No. 33 overall in the 2026 NFL Draft was partially motivated by the organization's strong belief in his personality, leadership and work ethic, according to Matt Barrow of The Athletic.
Kaelon Black
In RB2 mix behind CMC
Black is set to compete with recent draft picks Jordan James and Isaac Guerendo for backup touches behind Christian McCaffrey, Grant Gordon of NFL.com reports.
George Kittle
Aiming to play Week 1
Coach Kyle Shanahan said Thursday that Kittle (Achilles) is aiming to be ready for the 49ers' Week 1 game against the Rams, David Lombardi of SFStandard.com reports.