Exits Sunday's game
McCaffrey exited Sunday's game against the Commanders with a right calf injury and is questionable to return.
Prior to sustaining his calf injury, McCaffrey had carried 14 times for 64 yards and caught four of his five targets for 27 yards. If the star tailback is sidelined for the rest of Week 17, Elijah Mitchell would likely finish the contest as the 49ers' lead option on the ground.
More San Francisco 49ers Fantasy Football News
Jake Tonges
Taking part in camp
Tonges (foot) is participating in practice to begin training camp, Brooke Evans of the 49ers' official site reports.
Jordan James
Opens camp as RB2
James appears to be operating as the No. 2 running back behind Christian McCaffrey to begin training camp, Nick Wagoner of ESPN.com reports.
Christian Kirk
Walks off with trainer
Kirk walked off with an apparent injury during the 49ers' practice Sunday, Matt Barrows of The Athletic reports.
Brandon Aiyuk
Remains on left squad list
San Francisco general manager John Lynch told reporters Saturday that Aiyuk (knee) will remain on the 49ers' reserve/left squad list, Adam Schefter of ESPN reports.
George Kittle
Starting training camp on PUP
The 49ers placed Kittle (Achilles) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports.
Christian McCaffrey
Wins Best Comeback Athlete
McCaffrey was named the Best Comeback Athlete at the 2026 ESPYS, Briana Jeannel of the 49ers' official site reports.
Ricky Pearsall
Poised to start opposite Evans
Pearsall is expected to enter training camp as San Francisco's starting wide receiver opposite Mike Evans, Kyle Madson of USA Today reports.
Brock Purdy
Plans throwing sessions before camp
Purdy, who has been participating in this week's Tight End University, an event hosted by teammate George Kittle (Achilles), said that he plans to gather with other 49ers for throwing sessions over the next month prior to training camp, David Lombardi of the San Francisco Standard reports.
Brandon Aiyuk
Interested in joining Commanders
In a video posted to Instagram Wednesday, Aiyuk (knee) said that if the 49ers released him, he'd sign with the Commanders "tomorrow," ESPN.com reports.
George Kittle
Feels on track for Week 1
Kittle (Achilles) said Tuesday that he feels "definitely on track" for Week 1 though "nothing is 100 percent certain," David Lombardi of SFStandard.com reports.