Pacing league with 21 TDs
McCaffrey rushed 14 times for 103 yards and a touchdown while adding six receptions and 28 receiving yards off of 10 targets in Monday's 33-19 loss to the Ravens.
It was a disastrous night for the 49ers on the whole, but it's hard to point any fingers at McCaffrey after he logged the fourth 100-yard rushing game over his last five contests. The MVP candidate also punched in his 21st touchdown of the season, maintaining pace for the league lead with Miami's Raheem Mostert, who also registered his 21st score earlier in Week 16. McCaffrey has just set a new personal best in rushing yards over a single season with 1,395 through 15 games, surpassing the 1,387 rushing yards he posted during his incredible 2019 campaign with the Panthers. With just two games left in the regular season, McCaffrey should be afforded ample opportunities to bolster his award bids, startring with a road matchup against the Commanders on Dec. 31.
More San Francisco 49ers Fantasy Football News
Christian Kirk
Dealing with calf injury
Kirk sustained a calf injury during Sunday's practice and is not practicing Monday, Nick Wagoner of ESPN.com reports.
Jake Tonges
Taking part in camp
Tonges (foot) is participating in practice to begin training camp, Brooke Evans of the 49ers' official site reports.
Jordan James
Opens camp as RB2
James appears to be operating as the No. 2 running back behind Christian McCaffrey to begin training camp, Nick Wagoner of ESPN.com reports.
Christian Kirk
Walks off with trainer
Kirk walked off with an apparent injury during the 49ers' practice Sunday, Matt Barrows of The Athletic reports.
Brandon Aiyuk
Remains on left squad list
San Francisco general manager John Lynch told reporters Saturday that Aiyuk (knee) will remain on the 49ers' reserve/left squad list, Adam Schefter of ESPN reports.
George Kittle
Starting training camp on PUP
The 49ers placed Kittle (Achilles) on the active/PUP list Saturday, Matt Maiocco of NBC Sports Bay Area reports.
Christian McCaffrey
Wins Best Comeback Athlete
McCaffrey was named the Best Comeback Athlete at the 2026 ESPYS, Briana Jeannel of the 49ers' official site reports.
Ricky Pearsall
Poised to start opposite Evans
Pearsall is expected to enter training camp as San Francisco's starting wide receiver opposite Mike Evans, Kyle Madson of USA Today reports.
Brock Purdy
Plans throwing sessions before camp
Purdy, who has been participating in this week's Tight End University, an event hosted by teammate George Kittle (Achilles), said that he plans to gather with other 49ers for throwing sessions over the next month prior to training camp, David Lombardi of the San Francisco Standard reports.
Brandon Aiyuk
Interested in joining Commanders
In a video posted to Instagram Wednesday, Aiyuk (knee) said that if the 49ers released him, he'd sign with the Commanders "tomorrow," ESPN.com reports.