NFL DFS: DraftKings GPP Picks Week 16 (Fantasy Football)

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This article highlights plays with substantial upside for large-field GPPs. That doesn’t mean playing only these players and excluding the cash game plays. In fact, many top tournament lineups blend high-rostered anchors with lower-rostered leverage plays. Betz’s Cash Plays for Week 16 are HERE.

When building your GPP lineups, be sure to reference our Roster Percentage Report as well as our DFS Rankings to identify plays that have a solid projection yet may be undervalued by the field. For more on how to use roster percentages and build strong GPP lineups, be sure to check out this former episode of the DFS Podcast

*Note: Plays listed below are in order of salary, NOT necessarily ranked by preferred plays.

Quarterback

Houston Texans quarterback CJ. Stroud (7) warms up before an NFL football matchup at EverBank Stadium, Sunday, Sept. 21, 2025, in Jacksonville, Fla. The Jaguars defeated the Texans 17-10.

Corey Perrine/Florida Times-Union / USA TODAY NETWORK via Imagn Images

C.J. Stroud vs LV | $5,500
When you think of Stroud, it’s not exactly fireworks or upside because he doesn’t accrue fantasy points with his legs. But he’s done an excellent job over the last four games of not turning the ball over, averaging .25 INTs per game. The Raiders are third-worst at defending passes, allowing 69% to be completed. With Woody Marks and the RB room not 100% healthy, Stroud may be the engine that covers their current 14.5 line.

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