Initial diagnosis confirmed
San Francisco head coach Kyle Shanahan confirmed Monday that Hufanga suffered a season-ending ACL tear to his right knee in Sunday's 27-14 win over the Buccaneers, Josh Dubow of the Associated Press reports.
Shanahan had already said after the game Sunday that Hufanga had likely suffered a torn ACL, and follow-up tests on the safety's knee quickly confirmed as much. The loss of Hufanga is a devastating one for the San Francisco defense, as the 23-year-old has emerged as one of the NFL's premier safeties in his third season in the league. Over 10 appearances this season, Hufanga tallied 52 tackles and three interceptions.
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Jennings failed to haul in his lone target in Sunday's 28-16 win over Seattle.
Mason had four carries for 20 yards and a touchdown and a reception of six yards in Sunday's 28-16 win over the Seahawks.
Kittle had three receptions on five targets for 76 yards and a touchdown in Sunday's 28-16 win over the Seahawks.
Aiyuk had six receptions on nine targets for 126 yards while also losing a fumble in Sunday's 28-16 win over Seattle.
Purdy completed 19 of 27 pass attempts for 368 yards, two touchdowns and one interception while rushing twice for seven yards in Sunday's 28-16 win over Seattle.
Samuel caught seven of nine targets for 149 yards and a touchdown while scoring another touchdown on his lone carry of one yard in Sunday's 28-16 win over Seattle.
McCaffrey took 16 carries for 145 yards and caught his lone target for eight yards in Sunday's 28-16 win over the Seahawks.
Mason is in line to serve as the No. 2 running back for Sunday's Week 14 game against the Seahawks with Elijah Mitchell (knee) ruled inactive for the contest.
Mitchell (knee) is inactive for Sunday's Week 14 clash with Seattle.
Mitchell (knee) is listed as doubtful for Sunday's game against Seattle, Matt Barrows of The Athletic reports.