Initial diagnosis confirmed
San Francisco head coach Kyle Shanahan confirmed Monday that Hufanga suffered a season-ending ACL tear to his right knee in Sunday's 27-14 win over the Buccaneers, Josh Dubow of the Associated Press reports.
Shanahan had already said after the game Sunday that Hufanga had likely suffered a torn ACL, and follow-up tests on the safety's knee quickly confirmed as much. The loss of Hufanga is a devastating one for the San Francisco defense, as the 23-year-old has emerged as one of the NFL's premier safeties in his third season in the league. Over 10 appearances this season, Hufanga tallied 52 tackles and three interceptions.
More San Francisco 49ers Fantasy Football News

Jauan Jennings
WR | SF
No catches against SEA
Jennings failed to haul in his lone target in Sunday's 28-16 win over Seattle.
Jordan Mason
RB | SF
Scores TD spelling CMC
Mason had four carries for 20 yards and a touchdown and a reception of six yards in Sunday's 28-16 win over the Seahawks.

George Kittle
TE | SF
Burns defenders for sixth TD
Kittle had three receptions on five targets for 76 yards and a touchdown in Sunday's 28-16 win over the Seahawks.

Brandon Aiyuk
WR | SF
Surpasses century mark
Aiyuk had six receptions on nine targets for 126 yards while also losing a fumble in Sunday's 28-16 win over Seattle.

Brock Purdy
QB | SF
Tops previous best with 368 yards
Purdy completed 19 of 27 pass attempts for 368 yards, two touchdowns and one interception while rushing twice for seven yards in Sunday's 28-16 win over Seattle.

Deebo Samuel
WR | SF
Two more scores in win
Samuel caught seven of nine targets for 149 yards and a touchdown while scoring another touchdown on his lone carry of one yard in Sunday's 28-16 win over Seattle.

Christian McCaffrey
RB | SF
Runs wild on Seahawks
McCaffrey took 16 carries for 145 yards and caught his lone target for eight yards in Sunday's 28-16 win over the Seahawks.
Jordan Mason
RB | SF
Should serve as No. 2 back
Mason is in line to serve as the No. 2 running back for Sunday's Week 14 game against the Seahawks with Elijah Mitchell (knee) ruled inactive for the contest.

Elijah Mitchell
RB | SF
Officially inactive Sunday
Mitchell (knee) is inactive for Sunday's Week 14 clash with Seattle.

Elijah Mitchell
RB | SF
Doubtful after missed practices
Mitchell (knee) is listed as doubtful for Sunday's game against Seattle, Matt Barrows of The Athletic reports.