Efficient in Week 3 win
McCaffrey rushed 18 times for 85 yards and a touchdown and secured all five targets for 34 yards in the 49ers' 30-12 win over the Giants on Thursday night.
McCaffrey didn't put up the same level of numbers as he had in the first two weeks, but it wasn't necessary in a game when San Francisco re-established a double-digit lead early in the fourth quarter after also having enjoyed one in the first half. The latter advantage came courtesy of McCaffrey, who recorded a four-yard scoring rush with 1:40 remaining in the second quarter to extend a 10-3 lead. McCaffrey eclipsed the 100-yard mark in the first pair of contests, but the extra rest he got Thursday night combined with the additional time off before a Week 4 home matchup against the Cardinals on Sunday, Oct. 1 should be highly beneficial to San Francisco's most explosive player.
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Mitchell (knee) is listed as doubtful for Sunday's game against Seattle, Matt Barrows of The Athletic reports.
The 49ers have ruled McCloud out in advance of Sunday's game against the Seahawks, Matt Barrows of The Athletic reports.
Mitchell (knee) didn't practice Thursday, Josh Dubow of The Associated Press reports.
Mitchell won't take part in Wednesday's practice due to a knee injury, David Lombardi of The Athletic reports.
Mitchell rushed three times for 13 yards and was not targeted in the passing game in Sunday's 42-19 rout of the Eagles.
Jennings had three receptions on four targets for 44 yards and a touchdown in Sunday's 42-19 win over Philadelphia.
Aiyuk had five receptions on seven targets for 46 yards and a touchdown in Sunday's 42-19 rout of the Eagles.
Kittle had four receptions on six targets for 68 yards in Sunday's 42-19 win over the Eagles.
Purdy completed 19 of 27 pass attempts for 314 yards and four touchdowns in Sunday's 42-19 win over Philadelphia.
Samuel caught all four of his targets for 116 yards and two touchdowns while adding 22 rushing yards and another score off of three carries in Sunday's 42-19 win over the Eagles.