Diagnosed with ankle sprain
Barkley has been diagnosed with an ankle sprain following an MRI on Monday and isn't expected to play Thursday against the 49ers, Adam Schefter of ESPN reports.
Schefter says the injury is slated to sideline the superstar running back for three weeks and describes the sprain as "ordinary." While this isn't great news, it does appear Barkley avoided a serious injury and should be able to return relatively soon. Ian Rapoport of NFL.com reports that Barkley is considered week-to-week moving forward.
More New York Giants Fantasy Football News

Parris Campbell
WR | NYG
Secures three catches Monday
Campbell hauled in three of five targets for 15 yards Monday in a 24-3 loss to Seattle.
Jalin Hyatt
WR | NYG
Quiet again Week 4
Hyatt caught both of his targets for 10 yards Monday in a Week 4 loss to the Seahawks.

Isaiah Hodgins
WR | NYG
Gets just three targets Week 4
Hodgins caught all three of his targets for 24 yards against the Seahawks in a 24-3 loss on Monday Night Football.

Darius Slayton
WR | NYG
Two catches on MNF
Slayton caught two of three targets for 23 yards in Monday's 24-3 loss to the Seahawks.

Wan'Dale Robinson
WR | NYG
Has 11 targets in two games
Robinson caught five of six targets for 40 yards and added a seven-yard run in Monday's 24-3 loss to the Seahawks.

Darren Waller
TE | NYG
Another forgettable outing
Waller caught all three of his targets for 21 yards in Monday's 24-3 loss to the Seahawks.

Matt Breida
RB | NYG
Gets 19 touches in Week 4 loss
Breida rushed 14 times for 30 yards and caught all five of his targets for 48 yards in Monday's 24-3 loss to the Seahawks.

Daniel Jones
QB | NYG
Another dud on MNF
Jones completed 27 of 34 passes for 203 yards and rushed 10 times for 66 yards in Monday's 24-3 loss to the Seahawks. He was intercepted twice and fumbled twice, losing one.

Daniel Bellinger
TE | NYG
Night comes to early end
Bellinger (knee) has been ruled out for the remainder of Monday's contest with the Seahawks, Dan Salomone of the Giants' official site reports.

Daniel Bellinger
TE | NYG
Exits with knee injury
Bellinger suffered a knee injury and is questionable to return to Monday's contest with the Seahawks, Pat Leonard of the New York Daily News reports.