Erupts for 159 total yards
Cook rushed the ball 17 times for 123 yards and no touchdowns in Sunday's 38-10 win over the Raiders. He added four receptions on four targets for 36 yards.
Cook tallied the first 100-yard rushing performance of his pro career, which was powered by long gains of 36, 16 and 14 yards. While he held up his end of the deal, Cook's usage was somewhat concerning as Latavius Murray and Damien Harris combined to tally 13 carries with each also finding the end zone. It's possible that game script had something to do with the rotation at the position, but it will be an ongoing situation worth monitoring. Despite that lingering question, Cook has racked up 225 total yards through two games this season and has proven to be a worthy contributor in the Bills' offense.
More Buffalo Bills Fantasy Football News

Dawson Knox
TE | BUF
Practices fully, slated to play
Knox (back) practiced in full Friday and doesn't have an injury designation ahead of Sunday's Week 3 game against the Commanders.

James Cook
RB | BUF
Back at practice
Cook (personal) returned to practice Friday, Alaina Getzenberg of ESPN.com reports.

Dawson Knox
TE | BUF
Returning to practice
Knox (back) is in line to practice Friday, Alaina Getzenberg of ESPN.com reports.

James Cook
RB | BUF
Absent for personal reason
Cook missed Thursday's practice due to a personal matter, Chris Brown of the Bills' official site reports.

James Cook
RB | BUF
Not spotted at practice
Cook (undisclosed) wasn't spotted during the open portion of Thursday's practice, Alaina Getzenberg of ESPN.com reports.

Dawson Knox
TE | BUF
Not practicing again
Knox (back) won't practice Thursday, Katherine Fitzgerald of The Buffalo News reports.

Dawson Knox
TE | BUF
Not practicing Wednesday
Knox won't practice Wednesday due to a back injury, Chris Brown of the Bills' official site reports.

Trent Sherfield
WR | BUF
Uninvolved offensively
Sherfield has yet to be targeted through two games even though he's seen 39 snaps on offense.

Khalil Shakir
WR | BUF
Scores in romp over Raiders
Shakir caught his only target for 11 yards and a touchdown in Sunday's 38-10 win over the Raiders.

Latavius Murray
RB | BUF
Works ahead of Harris
Murray carried the ball six times for 22 yards and one touchdown in Sunday's 38-10 win over the Raiders. He added two receptions on two targets for nine yards.