Hurts ankle after scoring two TDs
Barkley (ankle) was helped off the field by training staff late in Sunday's 31-28 win over the Cardinals, Art Stapleton of The Record Sports reports. Barkley rushed 17 times for 63 yards and a touchdown while catching six of seven targets for 29 yards and another touchdown prior to the injury.
Barkley was injured with New York driving in the final minutes of a 28-28 game. Prior to getting hurt, Barkley helped the Giants erase a 20-0 halftime deficit with a one-yard rushing touchdown in the third quarter and a nine-yard touchdown catch in the fourth. Barkley was walking with a limp after the injury, per Adam Schefter of ESPN. The severity of the injury has yet to be determined, but even if it's relatively minor, Barkley could have a hard time healing up in time to face the 49ers on Thursday.
More New York Giants Fantasy Football News

Saquon Barkley
RB | NYG
Could be back for Week 4
Barkley (ankle) has "a chance" to get back on the field for the Giants' Week 4 game Oct. 2 versus the Seahawks, Ian Rapoport of NFL Network reports.
Jalin Hyatt
WR | NYG
Gets no targets in Thursday's loss
Hyatt didn't receive any targets against the 49ers in a Week 3 loss Thursday.

Parris Campbell
WR | NYG
Leads team in catches Thursday
Campbell caught all six of his targets for 24 yards in Week 3 during a loss to San Francisco.

Isaiah Hodgins
WR | NYG
Shut out Thursday
Hodgins failed to catch his only target in a Week 3 loss to San Francisco on Thursday.

Wan'Dale Robinson
WR | NYG
Four catches in season debut
Robinson (knee) secured four of five targets for 21 yards in the Giants' 30-12 loss to the 49ers on Thursday night.

Darren Waller
TE | NYG
Quiet night in loss
Waller secured three of six targets for 20 yards in the Giants' 30-12 loss to the 49ers on Thursday night.

Darius Slayton
WR | NYG
Leads team with modest yardage
Slayton secured three of six targets for 32 yards in the Giants' 30-12 loss to the 49ers on Thursday night.

Daniel Jones
QB | NYG
Significant downturn in Week 3 loss
Jones completed 22 of 32 passes for 137 yards with no touchdowns and one interception and added two rushes for five yards in the Giants' 30-12 loss to the 49ers on Thursday night.

Matt Breida
RB | NYG
Meager opportunity in loss
Breida rushed four times for 17 yards and a touchdown and brought in all three targets for one yard in the Giants' 30-12 loss to the 49ers on Thursday night.

Saquon Barkley
RB | NYG
Has 'high-ankle sprain'
Barkley isn't playing Thursday at San Francisco due to a "high-ankle sprain," Taylor Rooks reported on NFL on Prime's broadcast.