Remains limited by knee issue

McCaffrey was limited in practice Wednesday due to a knee injury, Eric Branch of the San Francisco Chronicle reports.

McCaffrey endured practice limitations last week with the same health concern, but he eventually ditched a designation on the final Week 13 injury report. He proceeded to have his second-most touches (25) in a 49ers uniform en route to 146 yards from scrimmage and a receiving TD this past Sunday against the Dolphins. Assuming he gets through this week unscathed, too, McCaffrey will be set to dominate the backfield work for the team Sunday versus the Buccaneers.

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Brandon Aiyuk

Brandon Aiyuk

WR | SF

Team seeking extension

49ers general manager John Lynch said Tuesday at the NFL Scouting Combine that the team wants to sign Aiyuk to a long-term contract extension, Eric Branch of the San Francisco Chronicle reports.

Deebo Samuel

Deebo Samuel

WR | SF

Powers through injury in OT loss

Samuel (hamstring) finished with three receptions (11 targets) for 33 yards while rushing three times for eight yards in Sunday's 25-22 overtime loss to the Chiefs.

Brock Purdy

Brock Purdy

QB | SF

Plays well in first SB appearance

Purdy completed 23 of 38 pass attempts for 255 yards and a touchdown while adding three carries for 12 yards in Sunday's 25-22 overtime loss to the Chiefs in Super Bowl LVIII.

Deebo Samuel

Deebo Samuel

WR | SF

Returns to Super Bowl

Samuel (hamstring) returned to Sunday's game against the Chiefs, Matt Maiocco of NBC Sports Bay Area reports.

Deebo Samuel

Deebo Samuel

WR | SF

Suffers hamstring injury

Samuel is questionable to return to Sunday's game against the Chiefs due to a hamstring injury, Ian Rapoport of NFL Network reports.

George Kittle

George Kittle

TE | SF

Set for Super Bowl

Kittle (toe) practiced fully Friday and doesn't have an injury designation for Super Bowl LVIII versus the Chiefs on Sunday.

Sam Darnold

Sam Darnold

QB | SF

Solid as backup in 2023

Darnold completed 61 percent of his pass attempts for 297 yards, two touchdowns and one interception across 10 games (one start) with San Francisco in 2023.