Managing knee issue
McCaffrey will be managed day-to-day, as the running back is dealing with what coach Kyle Shanahan has described as knee irritation, Nick Wagoner of ESPN.com reports.
At this stage, there's nothing to suggest that McCaffrey is in danger of missing Sunday's game against the Dolphins, but it appears as though his practice reps will be managed this week. With Elijah Mitchell slated to miss 6-to-8 weeks with an MCL injury, McCaffrey is in line to continue to lead the 49ers' ground game in the coming weeks, with Jordan Mason and Tyrion Davis-Price set to work in change-of-pace/complementary roles and Tevin Coleman a candidate to be promoted from the team's practice squad.
More San Francisco 49ers Fantasy Football News
49ers general manager John Lynch said Tuesday at the NFL Scouting Combine that the team wants to sign Aiyuk to a long-term contract extension, Eric Branch of the San Francisco Chronicle reports.
Kittle caught two of three targets for four yards in Sunday's 25-22 overtime loss to the Chiefs in Super Bowl LVIII.
Aiyuk had three receptions on six targets for 49 yards in a 25-22 overtime loss to the Chiefs in Super Bowl LVIII.
Samuel (hamstring) finished with three receptions (11 targets) for 33 yards while rushing three times for eight yards in Sunday's 25-22 overtime loss to the Chiefs.
Purdy completed 23 of 38 pass attempts for 255 yards and a touchdown while adding three carries for 12 yards in Sunday's 25-22 overtime loss to the Chiefs in Super Bowl LVIII.
McCaffrey rushed 22 times for 80 yards while corralling all eight of his targets for 80 yards and a touchdown in a 25-22 overtime loss to the Chiefs in Super Bowl LVIII.
Samuel (hamstring) returned to Sunday's game against the Chiefs, Matt Maiocco of NBC Sports Bay Area reports.
Samuel is questionable to return to Sunday's game against the Chiefs due to a hamstring injury, Ian Rapoport of NFL Network reports.
Kittle (toe) practiced fully Friday and doesn't have an injury designation for Super Bowl LVIII versus the Chiefs on Sunday.
Darnold completed 61 percent of his pass attempts for 297 yards, two touchdowns and one interception across 10 games (one start) with San Francisco in 2023.