Sunday status TBD

Though the Panthers have reportedly been optimistic about McCaffrey playing Sunday against the Cardinals, the running back is expected to test out his thigh injury in pregame warmups to determine his availability for the contest, Jeremy Fowler of ESPN.com reports.

Those considering McCaffrey in Week 4 fantasy lineups will want to confirm his status when the Panthers' inactives are posted ahead of Sunday's 4:05 ET kickoff. In the event that he ends up out or limited, Chuba Hubbard and D'Onta Foreman would be in line to handle expanded roles out of the Panthers backfield versus Arizona.

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More San Francisco 49ers Fantasy Football News

Brock Purdy

QB | SF

Takes over for injured starter

Purdy completed 25 of 37 pass attempts for 210 yards, two touchdowns and an interception in relief of Jimmy Garoppolo (foot) in Sunday's 33-17 win over Miami.

Deebo Samuel

Deebo Samuel

WR | SF

Gains 63 yards on 10 touches

Samuel (quadriceps) had six receptions on 10 targets for 58 yards and rushed four times for five yards in Sunday's 33-17 win over the Dolphins.

Carries offense in big win

McCaffrey (knee) carried the ball 17 times for 66 yards while adding eight receptions on 10 targets for 80 yards and a touchdown in Sunday's 33-17 win over the Dolphins.

Jimmy Garoppolo

Jimmy Garoppolo

QB | SF

Ruled out for season

Garoppolo sustained a broken foot Sunday against the Dolphins and will miss the remainder of the season, Nick Wagoner of ESPN.com reports.