Bothered by thigh, not practicing

McCaffrey didn't practice Wednesday due to a thigh issue, though his injury isn't believed to be serious, David Newton of ESPN.com reports.

McCaffrey usually rests on Wednesdays anyway, but this week he actually has an injury, albeit a minor one. Head coach Matt Rhule suggested McCaffrey could return to practice as soon as Thursday, which would likely erase most of the concern about his ability to play in Sunday's game against the Cardinals. If the injury were to threaten McCaffrey's availability, the Panthers would turn to Chuba Hubbard and D'Onta Foreman in the backfield.

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More San Francisco 49ers Fantasy Football News

Jimmy Garoppolo

Jimmy Garoppolo

QB | SF

Avoiding foot surgery

Garoppolo won't need surgery on his broken left foot, which has been confirmed to not be a Lisfranc injury, Adam Schefter of ESPN reports. If his recovery goes well, Garoppolo may be able to return in 7-to-8 weeks.

Nick Bosa

Nick Bosa

DL | SF

Dealing with minor injury

San Francisco coach Kyle Shanahan said that Bosa is dealing with a "hamstring irritation" that the team will work through ahead of Week 14 game against Tampa Bay, David Lombardi of The Athletic reports.

Jimmy Garoppolo

Jimmy Garoppolo

QB | SF

Still undergoing tests on foot

Coach Kyle Shanahan said Monday that Garoppolo continues to undergo testing on his broken left foot, but there's a growing belief that the quarterback avoided a Lisfranc injury, David Lombardi of The Athletic reports.

Brock Purdy

QB | SF

Takes over for injured starter

Purdy completed 25 of 37 pass attempts for 210 yards, two touchdowns and an interception in relief of Jimmy Garoppolo (foot) in Sunday's 33-17 win over Miami.