Trey Lance, QB (SF)

Set for season-ending surgery

Head coach Kyle Shanahan said Lance suffered a broken right ankle in Sunday's win over the Seahawks and will undergo season-ending surgery Monday, Eric Branch of the San Francisco Chronicle reports.

Fears of a season-ending injury immediately circulated when Lance was carted off the field in the first quarter of Sunday's contest, and Shanahan confirmed hours later that the second-year quarterback won't play again in 2022. Jimmy Garoppolo replaced the injured Lance and helped lead the 49ers to a 27-7 win. It's a tough setback for Lance in just the second game of his first season as a starter, after he often watched from the sidelines as Garoppolo's understudy during his rookie season.

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Jeff Wilson Jr.

Jeff Wilson Jr.

RB | SF

Loses fumble late

Wilson rushed 12 times for 75 yards while adding three receptions for 31 yards in Sunday's 11-10 loss to Denver.

George Kittle

George Kittle

TE | SF

Cleared for Sunday

Kittle (groin) has been cleared for Sunday's game against Denver, avoiding a designation on the 49ers' final injury report, Nick Wagoner of ESPN.com reports.

George Kittle

George Kittle

TE | SF

Limited again Wednesday

Head coach Kyle Shanahan said Kittle (groin) will be a limited practice participant Wednesday, Nick Wagoner of ESPN.com reports.