No practice Wednesday
Samuel (groin) didn't practice Wednesday, Eric Branch of the San Francisco Chronicle reports.
With a 1-to-2-game absence imminent due to a groin strain, Samuel likely will log DNPs all week before the 49ers rule him out for Sunday's contest at Seattle. In his absence, the 49ers will rely on Brandon Aiyuk, Jauan Jennings, Trent Sherfield and Travis Benjamin at wide receiver, while River Cracraft and Connor Wedington are candidates to be elevated from the practice squad for game day.
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Bell caught both of his targets for 24 yards and a touchdown in Thursday's 30-12 win over the Giants.
McCloud logged 38 offensive snaps (46 percent) but was not targeted in Thursday's 30-12 win over the Giants.
Jennings caught two of three targets for 31 yards in Thursday's 30-12 win over the Giants.
Samuel's ribs are sore after a win over the Giants on Thursday, but testing didn't reveal any breaks or serious damage, Nick Wagoner of ESPN.com reports.
Mitchell rushed 11 times for 42 yards and secured all three targets for two yards in the 49ers' 30-12 win over the Giants on Thursday night.
Kittle secured seven of nine targets for 90 yards in the 49ers' 30-12 win over the Giants on Thursday night.
Samuel brought in six of 12 targets for 129 yards and a touchdown and rushed once for two yards in the 49ers' 30-12 win over the Giants on Thursday night.
Purdy completed 25 of 37 passes for 310 yards with two touchdowns and no interceptions while rushing four times for minus-1 yard in the 49ers' 30-12 win over the Giants on Thursday night. He also fumbled once but recovered.
McCaffrey rushed 18 times for 85 yards and a touchdown and secured all five targets for 34 yards in the 49ers' 30-12 win over the Giants on Thursday night.
McCloud is lining up with the 49ers' starting offense Thursday against the Giants, Matt Barrows of The Athletic reports.