Sprained ankle to result in absence
Sermon has been diagnosed with an ankle sprain, and coach Kyle Shanahan said that the rookie third-round pick could land on injured reserve, Nick Wagoner of ESPN.com reports.
Sermon left Sunday's eventual win over the Vikings due to a right ankle injury and was unable to return. Prior to his departure, he managed to play four snaps on special teams but none on offense as Elijah Mitchell (finger) was back in the fold following a one-game absence. Behind Mitchell, expect Jeff Wilson to handle the bulk of the backfield work that lingers while Sermon is sidelined.
More San Francisco 49ers Fantasy Football News

Jimmy Garoppolo
QB | SF
Could land with Cleveland?
The Browns will consider acquiring Garoppolo if Deshaun Watson's six-game suspension is significantly increased upon appeal by the NFL, Mary Kay Cabot of the Cleveland Plain Dealer reports.

Trey Sermon
RB | SF
May be featured Friday night
Sermon was busy at Wednesday's practice and could see a lot of work Friday night against the Packers, Nick Wagoner of ESPN.com reports.

Brandon Aiyuk
WR | SF
Praised by veteran teammates
Aiyuk has made a strong impression on teammates and reporters alike, with safety Jimmie Ward saying the wideout is "taking his game to another level" and ESPN's Nick Wagoner calling him "the team's most consistent offensive performer" at training camp.

Willie Snead IV
WR | SF
Signs with San Fran
Snead signed a contract with the 49ers on Friday, Aaron Wilson of Pro Football Network reports.

Brandon Aiyuk
WR | SF
Shining in training camp
Aiyuk has excelled in training camp for the 49ers, Jennifer Lee Chan of NBC Sports Bay Area reports.

Jimmy Garoppolo
QB | SF
Shows off arm Tuesday
Garoppolo (shoulder) went through a throwing regimen on a side field at the same time as the 49ers practiced Tuesday, Matt Maiocco of NBC Sports Bay Area reports.

Deebo Samuel
WR | SF
Will ramp up workload
Coach Kyle Shanahan said Monday that the 49ers will ease Samuel back up to a full workload at practice, Jennifer Lee Chan of NBC Sports Bay Area reports.

Deebo Samuel
WR | SF
Inks massive extension
Samuel and the 49ers agreed to a three-year, $73.5 million contract extension Sunday, Ian Rapoport of NFL Network reports.

George Kittle
TE | SF
Past lower-body issue
Kittle, who dealt with a lower-body issue during OTAs, is participating in training camp practices, David Lombardi of The Athletic reports.

Elijah Mitchell
RB | SF
Healthy to open training camp
Mitchell (knee) worked with the first-team offense at San Francisco's first practice of training camp, Jennifer Lee Chan of NBC Sports Bay Area reports.