Trey Lance, QB (SF)

Ruled out

Lance (knee) has been ruled out for Sunday's game against the Colts, Cam Inman of The San Jose Mercury News reports.

Lance won't be available this week, but fellow quarterback Jimmy Garoppolo has been cleared to return from a calf injury. Both guys figure to contribute to the team this year, but Lance's Week 5 start against the Cardinals didn't exactly bolster his case for more playing time. The ankle injury also doesn't help, though it'll likely heal within the next few weeks. That said, Lance didn't practice at all this week.

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JaMycal Hasty

JaMycal Hasty

RB | SF

Limited Wednesday

Hasty (ankle) was a limited practice participant Wednesday, Eric Branch of the San Francisco Chronicle reports.

Fred Warner

Fred Warner

LB | SF

Likely unavailable Sunday

Warner (hamstring) will likely be unavailable for Sunday's matchup against the Seahawks, Cam Inman of The San Jose Mercury News reports.

Trey Sermon

RB | SF

Sprained ankle to result in absence

Sermon has been diagnosed with an ankle sprain, and coach Kyle Shanahan said that the rookie third-round pick could land on injured reserve, Nick Wagoner of ESPN.com reports.

Jeff Wilson Jr.

Jeff Wilson Jr.

RB | SF

Resumes reserve role

Wilson had two carries for five yards and caught his lone target for two more yards in Sunday's 34-26 win over the Vikings.

Trent Sherfield

Trent Sherfield

WR | SF

Re-enters wideout rotation

Sherfield was on the field for 20 offensive snaps (27 percent) and caught his lone target for five yards in Sunday's 34-26 win over Minnesota.