Trey Lance, QB (SF)

No practice reps Wednesday

Lance (knee) won't participate in practice Wednesday, Matt Barrows of The Athletic reports.

In fact, Lance isn't expected to be available at all Sunday at Indianapolis, while Jimmy Garoppolo eases his way into practice as a limited participant Wednesday, according to Nick Wagoner of ESPN.com. With Garoppolo slated to be under center Week 7 and Lance seemingly trending toward an absence, the 49ers will roll with Nate Sudfeld as their backup QB.

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Fred Warner

Fred Warner

LB | SF

Likely unavailable Sunday

Warner (hamstring) will likely be unavailable for Sunday's matchup against the Seahawks, Cam Inman of The San Jose Mercury News reports.

Trey Sermon

RB | SF

Sprained ankle to result in absence

Sermon has been diagnosed with an ankle sprain, and coach Kyle Shanahan said that the rookie third-round pick could land on injured reserve, Nick Wagoner of ESPN.com reports.

Jeff Wilson Jr.

Jeff Wilson Jr.

RB | SF

Resumes reserve role

Wilson had two carries for five yards and caught his lone target for two more yards in Sunday's 34-26 win over the Vikings.

Trent Sherfield

Trent Sherfield

WR | SF

Re-enters wideout rotation

Sherfield was on the field for 20 offensive snaps (27 percent) and caught his lone target for five yards in Sunday's 34-26 win over Minnesota.