Trey Lance, QB (SF)

Uneven in first start

Lance completed 15-of-29 passes for 192 yards and an interception against Arizona on Sunday, adding 89 yards on 16 carries.

Coach Kyle Shanahan said after the game that Jimmy Garoppolo (calf) remains the starting quarterback when healthy, so whenever his health allows a return to the field, the 49ers appear intent to get him back into the starting lineup. San Francisco is 2-3 and any further losses in the short term could really harm their odds of making the playoffs. The 49ers have a bye in Week 6 before facing the Colts in Week 7, but it's not clear where Garoppolo will be in his recovery by then.

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JaMycal Hasty

JaMycal Hasty

RB | SF

Limited Wednesday

Hasty (ankle) was a limited practice participant Wednesday, Eric Branch of the San Francisco Chronicle reports.

Fred Warner

Fred Warner

LB | SF

Likely unavailable Sunday

Warner (hamstring) will likely be unavailable for Sunday's matchup against the Seahawks, Cam Inman of The San Jose Mercury News reports.

Trey Sermon

RB | SF

Sprained ankle to result in absence

Sermon has been diagnosed with an ankle sprain, and coach Kyle Shanahan said that the rookie third-round pick could land on injured reserve, Nick Wagoner of ESPN.com reports.

Jeff Wilson Jr.

Jeff Wilson Jr.

RB | SF

Resumes reserve role

Wilson had two carries for five yards and caught his lone target for two more yards in Sunday's 34-26 win over the Vikings.

Trent Sherfield

Trent Sherfield

WR | SF

Re-enters wideout rotation

Sherfield was on the field for 20 offensive snaps (27 percent) and caught his lone target for five yards in Sunday's 34-26 win over Minnesota.